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Resveratrol increased satiety and metabolism, causing a reduced weight gain in non-human primates in a recent study (BMC Physiol. 2010 Jun 22;10(1):11). Researchers found the red-wine compound caused lemurs to gain less weight during their seasonal fattening period.
Resveratrol, a natural polyphenolic compound, has been shown to protect rodents against high-fat-diet induced diabetes by boosting energy metabolism. However, until now, the effects of resveratrol’s effects on metabolism had not been studied in non-human primates.
Researchers gave six non-human heterotherm primates (grey mouse lemurs, Microcebus murinus) with resveratrol supplements (200 mg/kg/day) for four weeks during their winter body-mass gain period. Body mass, spontaneous energy intake, resting metabolic rate, spontaneous locomotor activity and daily variations in body temperature were measured. In addition, the plasma levels of several gut hormones involved in satiety control were evaluated.
The lemurs in the study ate 13-percent fewer calories, and their resting metabolic rate was increased by 29 percent, causing less seasonal body-mass gain. Reseachers noted the lemurs’ activity levels were unchanged, and except for an increase in the glucose-dependent insulinotropic polypeptide, a gut hormone known to promote mobilization of fat stores, no major change in satiety hormone plasma levels occurred. Resveratrol supplementation also inhibited the depth of daily torpor, an important energy-saving process in this primate.
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