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Pain and Inflammation

Research confirms that Omega 3 and Resveratrol help to control inflammation and pain associated with musculoskeletal inflammatory conditions. Natural Biology recommends the following products for support:

  • Vintage Resveratrol 100% - the purest source of naturally occurring Resveratrol
  • Arctic Ocean Krill Oil or Norwegian Omega 3 - two of the purest sources of Omega 3
  • VITA-TRATES - contains Resveratrol and Omega 3s as well as Seaweed minerals

Omega-3 (EPA and DHA

EPA and DHA are essential omega-3 fatty acids from fish oil that are well known to promote healthy inflammatory balance. By acting as substrates for the body’s various anti-inflammatory mediators, EPA and DHA are essential to the resolution of inflammatory processes as well as tissue repair in all types of tissues. Studies demonstrate the efficacy of EPA and DHA in reducing pain associated with musculoskeletal inflammatory conditions. EPA and DHA decrease inflammation in connective tissue such as joints, thus helping to maintain connective tissue health and comfort. These omega-3 fatty acids also prevent bone loss and cartilage degradation in in vitro and animal studies. A meta-analysis of 17 randomized, controlled trials assessing the pain relieving effects of omega-3 fatty acids supplements concluded that supplementation for 3–4 months significantly reduces intensity, stiffness, number of painful and/or tender joints. C-reactive protein (CRP) is an inflammatory marker found in the blood, the levels of which rise in response to inflammation. Studies show that the higher the omega-3 levels in the blood of healthy individuals, the lower the CRP concentration. Supplementation with EPA and DHA has been shown in some, although not all, studies to decrease CRP levels as well as other biomarkers of inflammation in the blood. Published clinical trials and case studies also demonstrate the important role of EPA/DHA in supporting the health of the cardiovascular, immune, and nervous systems including mood.

Resveratrol

Resveratrol is a potent anti-inflammatory which decreases blood indices of oxidative and inflammatory stress. Like curcumin, resveratrol decreases inflammatory cytokines such as interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) by inhibiting NF-KappaB signaling. Results from human trials confirming resveratrol’s clinical benefits are beginning to emerge. Clinical studies of average weight adults have begun. Blood indices of oxidative and inflammatory stress were measured and resveratrol was found to induce significant reductions in reactive oxygen species generation, NF-kappaB binding, and numerous pro-inflammatory markers including TNF-alpha, IL-6, and C-reactive protein compared with the baseline and the placebo. Resveratrol, like curcumin, significantly decreases sensitivity to pain in animal studies. Pro-inflammatory molecules known as cytokines are key players in the development of back and leg pain resulting from unhealthy discs and spinal nerves. By decreasing pro-inflammatory cytokines, resveratrol significantly reduces pain behavior in rodents with disc-related pain. Signaling pathways in various types of joint cells can malfunction during aging, causing joint destruction and pain. When used together, resveratrol and curcumin have been shown to work synergistically to target multiple cellular signaling pathways in joint cells, effectively decreasing inflammation without adverse systemic effects.22 Resveratrol alone suppressed inflammation and destruction of inflamed joint cells in vitro.