High Blook Vitamin D Levels Reduce Prostate Cancer Risk Major Study Results
High blood vitamin D levels reduce risk of prostate cancer
The 2005 Multidisciplinary Prostate Cancer Symposium held in Orlando, Florida this month was the site of a presentation by Haojie Li MD, PhD of Harvard University School of Public Health of the finding that high plasma vitamin D levels could help protect against the development of prostate cancer and may also prevent the more aggressive form of the disease.
Using blood samples obtained in 1982 from 2400 healthy participants in the Physician’s Health Study, Dr Li and colleagues measured 25-hydroxyvitamin D (25 D) and 1,25 dihydroxyvitamin D (1,25 D), and ascertained variations in the vitamin D receptor gene. Samples from 1,029 men who developed prostate cancer over the 13 to 18 year follow-up period were age and smoking-status matched with blood from 1,371 healthy men.
The Harvard and Brigham and Women’s Hospital researchers found that men whose plasma levels of both forms of the vitamin were higher than the median of the current study population experienced a 45 percent lower risk of developing aggressive prostate cancer than those with lower levels. Presence of a genotype called homozygous Fokl FF combined with high vitamin D levels lowered overall risk by 55 percent, and the risk of developing aggressive disease by 77 percent.
Dr Li, who was the study’s lead investigator, concluded, "Our findings suggest that vitamin D plays an important protective role against prostate cancer, especially clinically aggressive disease. This research underscores the importance of obtaining adequate vitamin D through skin exposure to sunlight or through diet, including food and supplements."
Using blood samples obtained in 1982 from 2400 healthy participants in the Physician’s Health Study, Dr Li and colleagues measured 25-hydroxyvitamin D (25 D) and 1,25 dihydroxyvitamin D (1,25 D), and ascertained variations in the vitamin D receptor gene. Samples from 1,029 men who developed prostate cancer over the 13 to 18 year follow-up period were age and smoking-status matched with blood from 1,371 healthy men.
The Harvard and Brigham and Women’s Hospital researchers found that men whose plasma levels of both forms of the vitamin were higher than the median of the current study population experienced a 45 percent lower risk of developing aggressive prostate cancer than those with lower levels. Presence of a genotype called homozygous Fokl FF combined with high vitamin D levels lowered overall risk by 55 percent, and the risk of developing aggressive disease by 77 percent.
Dr Li, who was the study’s lead investigator, concluded, "Our findings suggest that vitamin D plays an important protective role against prostate cancer, especially clinically aggressive disease. This research underscores the importance of obtaining adequate vitamin D through skin exposure to sunlight or through diet, including food and supplements."
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