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Resveratrol Research

Natural Biology has been a leader in providing the highest quality resveratrol found in nature.  Our research indicates only French Red Wine Grape Extract with no less than 5% trans-resveratrol offers the efficacy, purity, and potency that works in humans.  A lot of companies offer polygonum cuspidatum extracts which have little human value.

The heart of longevity research today, resveratrol is a naturally occurring compound in plants called a phytoalexin, which means that it attacks pathogens that damage the plant, effectively acting as the plant's immune system. In animals such as fruit flies, nematode worms, fish and mice, it has been shown to significantly extend lifespan. Studies in mice have shown additional benefits such as less weight gain, increased physical endurance, improved liver health and hardier insulin sensitivity. It has not been proven conclusively to lead to any of these results in humans, but current research is promising.

Dr. David Sinclair, a researcher at the Harvard Medical School, is on the forefront of resveratrol research into longevity. Passionate about the science and study of aging, as a young man in 1999 he was recruited by Harvard Medical School due to his findings about sirtuins, a type of protein which assists in the repair of DNA. In his studies of yeast and later of small mammals, he found that when the DNA structure deteriorates, the resulting genomic instability causes the body to age.

Dr. Sinclair has since focused his energies on the health-giving properties of resveratrol. There are many: it has been shown to prevent skin cancer in mice, it significantly improves glucose stability in the blood (essential for diabetics), it creates faster metabolism (causing less weight gain), and it significantly reduced plaque formation in the brain (a leading cause of Alzheimer's disease). His research, however, has led full circle, back to the aging process and how resveratrol may slow it. It is a powerful antioxidant, assisting in the capture of free radicals throughout the body.

In addition to all these benefits, Dr. Sinclair believes that resveratrol activates the human sirtuin gene SIRT-1, which has already been proven to slow the effects of aging in humans through regulation and repair of DNA. SIRT-1, also known as the "survival gene" among geneticists, is generally only activated through radiation, infection or starvation, and prolongs the time a cell has to repair its DNA. This is designed as a biological survival mechanism. It has long been known that people who are consistently hungry tend to live longer than people who aren't, but this provides some scientific evidence as to why that is the case.

His studies at Harvard so far have yielded impressive results, and the whole medical world is talking about it. The recent article in Nature magazine catapulted the research into the public world, and have made everyone excited about the possibility of significantly increased lifespans. Perhaps the most popularized notion has been the discovery of significant quantities of resveratrol in red wine.

Notably found in highest concentration in the French Red Wines,  the fact that red wine could be the key to longevity has stunned researchers and laypeople alike. The benefits of red wine as a strong antioxidant have long been known, and recent nutritional reports have indicated that people who drink a glass of red wine a day tend to have healthier hearts than people who don't; now, it's been shown that a glass of red wine contains the same amount of resveratrol that Dr. Sinclair believes would be necessary for a human to achieve the same results as with his mice.